Identification of Sensitive Serum microRNA Biomarkers for Radiation Biodosimetry

Identification of Sensitive Serum microRNA Biomarkers for Radiation Biodosimetry

Exposure to ionizing radiation through environmental, occupational or a nuclear reactor accident such as the recent Fukushima Daiichi incident often results in major consequences to human health. The injury caused by radiation can manifest as acute radiation syndromes within weeks in organs with proliferating cells such as hematopoietic and gastrointestinal systems. Cancers, fibrosis and degene...

Serum microRNAs – potent biomarkers for radiation biodosimetry

Identification of Serum microRNA Biomarkers for Tuberculosis Using RNA-seq

Tuberculosis (TB) remains a significant human health issue. More effective biomarkers for use in tuberculosis prevention, diagnosis, and treatment, including markers that can discriminate between healthy individuals and those with latent infection, are urgently needed. To identify a set of such markers, we used Solexa sequencing to examine microRNA expression in the serum of patients with activ...

Gene-Expression Biomarkers for Application to High-Throughput Radiation Biodosimetry

Molecular biodosimetry tools are a valuable asset for life-saving medical triage and patient management following a radiological or nuclear disaster. Even with the delayed onset of symptoms, sometimes several days after exposure, gene-expression biomarkers can identify these exposed individuals very early after exposure, allowing for prompt medical intervention. This early assessment of a radia...

Microrna Biomarkers For Identification Of Chondrosarcoma